Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Coenzyme Q10 (CoQ10)
100 mg
**
Top Medical Research Studies
9
We explored the effects of coenzyme Q10 (CoQ-10) on heart failure (HF) patients by analyzing past literature. Our systematic review examined studies from MEDLINE and the Cochrane Library, focusing on how CoQ-10 influences outcomes like HF-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.
In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.
In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
Read More
9
CoQ10 protects against heart injury
We explored the protective effects of Coenzyme Q10 (CoQ10) and its liposomal form on heart health, particularly in response to copper toxicity caused by copper sulfate (CuSO4). In this study, rats received daily doses of CuSO4 to induce heart injury, while some were also treated with CoQ10 or L-CoQ10 to see if these supplements could mitigate the damage.
The results showed that CuSO4 led to elevated cardiac injury markers and increased oxidative stress, which is known to contribute to heart issues. However, the inclusion of CoQ10 and L-CoQ10 helped lower the levels of harmful markers, improve antioxidant capacity, and reduce inflammation. These supplements effectively restored balance and reduced signs of heart injury, highlighting their potential cardioprotective roles.
Overall, the findings suggest that CoQ10 could serve as a valuable defense for individuals at risk of copper toxicity, reinforcing its relevance in supporting cardiovascular health.
The results showed that CuSO4 led to elevated cardiac injury markers and increased oxidative stress, which is known to contribute to heart issues. However, the inclusion of CoQ10 and L-CoQ10 helped lower the levels of harmful markers, improve antioxidant capacity, and reduce inflammation. These supplements effectively restored balance and reduced signs of heart injury, highlighting their potential cardioprotective roles.
Overall, the findings suggest that CoQ10 could serve as a valuable defense for individuals at risk of copper toxicity, reinforcing its relevance in supporting cardiovascular health.
Read More
9
We explored the effectiveness of coenzyme Q10 in treating heart failure through a thorough analysis of various randomized controlled trials. Our investigation involved a comprehensive search across numerous databases, looking specifically for studies that focused on the impact of coenzyme Q10 on heart failure patients.
The findings were quite promising. We observed that coenzyme Q10 not only reduced the rate of all-cause mortality but also decreased hospitalizations due to heart failure. Improvements were noted in several key health metrics such as the New York Heart Association classification and brain natriuretic peptide levels. Furthermore, participants benefited from enhanced left ventricular ejection fraction and better performance on the six-minute walk test.
Importantly, these benefits were achieved without major adverse effects, suggesting that coenzyme Q10 could be a safe and effective option for those managing heart failure. Overall, our analysis indicates that coenzyme Q10 offers significant advantages for heart failure patients, enhancing their quality of life and potentially extending longevity.
The findings were quite promising. We observed that coenzyme Q10 not only reduced the rate of all-cause mortality but also decreased hospitalizations due to heart failure. Improvements were noted in several key health metrics such as the New York Heart Association classification and brain natriuretic peptide levels. Furthermore, participants benefited from enhanced left ventricular ejection fraction and better performance on the six-minute walk test.
Importantly, these benefits were achieved without major adverse effects, suggesting that coenzyme Q10 could be a safe and effective option for those managing heart failure. Overall, our analysis indicates that coenzyme Q10 offers significant advantages for heart failure patients, enhancing their quality of life and potentially extending longevity.
Read More
Most Useful Reviews
7.5
Boosted immunity
1 people found this helpful
Since taking Coenzyme Q10, I have experienced improved immune system function and have aided my cardiovascular disease.
Read More
7.5
Good for wellness
It is a good form for digestibility. The small capsules are easy to drink and swallow. It greatly helps with wellness, cardiovascular health, and beauty. I take two capsules daily as advised by my endocrinologist.
Read More
7.5
Very helpful
A very good product that has truly assisted me with my cardiovascular health.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
- All Researches
9
CoQ10 protects against heart injury
We explored the protective effects of Coenzyme Q10 (CoQ10) and its liposomal form on heart health, particularly in response to copper toxicity caused by copper sulfate (CuSO4). In this study, rats received daily doses of CuSO4 to induce heart injury, while some were also treated with CoQ10 or L-CoQ10 to see if these supplements could mitigate the damage.
The results showed that CuSO4 led to elevated cardiac injury markers and increased oxidative stress, which is known to contribute to heart issues. However, the inclusion of CoQ10 and L-CoQ10 helped lower the levels of harmful markers, improve antioxidant capacity, and reduce inflammation. These supplements effectively restored balance and reduced signs of heart injury, highlighting their potential cardioprotective roles.
Overall, the findings suggest that CoQ10 could serve as a valuable defense for individuals at risk of copper toxicity, reinforcing its relevance in supporting cardiovascular health.
The results showed that CuSO4 led to elevated cardiac injury markers and increased oxidative stress, which is known to contribute to heart issues. However, the inclusion of CoQ10 and L-CoQ10 helped lower the levels of harmful markers, improve antioxidant capacity, and reduce inflammation. These supplements effectively restored balance and reduced signs of heart injury, highlighting their potential cardioprotective roles.
Overall, the findings suggest that CoQ10 could serve as a valuable defense for individuals at risk of copper toxicity, reinforcing its relevance in supporting cardiovascular health.
Read More
9
We explored the effectiveness of coenzyme Q10 in treating heart failure through a thorough analysis of various randomized controlled trials. Our investigation involved a comprehensive search across numerous databases, looking specifically for studies that focused on the impact of coenzyme Q10 on heart failure patients.
The findings were quite promising. We observed that coenzyme Q10 not only reduced the rate of all-cause mortality but also decreased hospitalizations due to heart failure. Improvements were noted in several key health metrics such as the New York Heart Association classification and brain natriuretic peptide levels. Furthermore, participants benefited from enhanced left ventricular ejection fraction and better performance on the six-minute walk test.
Importantly, these benefits were achieved without major adverse effects, suggesting that coenzyme Q10 could be a safe and effective option for those managing heart failure. Overall, our analysis indicates that coenzyme Q10 offers significant advantages for heart failure patients, enhancing their quality of life and potentially extending longevity.
The findings were quite promising. We observed that coenzyme Q10 not only reduced the rate of all-cause mortality but also decreased hospitalizations due to heart failure. Improvements were noted in several key health metrics such as the New York Heart Association classification and brain natriuretic peptide levels. Furthermore, participants benefited from enhanced left ventricular ejection fraction and better performance on the six-minute walk test.
Importantly, these benefits were achieved without major adverse effects, suggesting that coenzyme Q10 could be a safe and effective option for those managing heart failure. Overall, our analysis indicates that coenzyme Q10 offers significant advantages for heart failure patients, enhancing their quality of life and potentially extending longevity.
Read More
9
We explored the effects of coenzyme Q10 (CoQ-10) on heart failure (HF) patients by analyzing past literature. Our systematic review examined studies from MEDLINE and the Cochrane Library, focusing on how CoQ-10 influences outcomes like HF-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.
In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.
In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
Read More
We conducted a thorough investigation into the effects of coenzyme Q10 on cardiovascular health in patients suffering from Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD). In this well-structured study, we utilized a randomized double-blind approach, dividing sixty participants to receive either 240 mg of coenzyme Q10 or a placebo daily for six months.
Our findings revealed that those taking coenzyme Q10 experienced significant improvements in several cardiovascular and liver health markers. Specifically, we noted reduced liver fat and enhanced endothelial function, indicating healthier blood vessels. Measurements showed positive changes in their vascular and myocardial functions, which are critical indicators of heart health.
Conversely, patients in the placebo group did not show any improvement throughout the study period. The results were compelling, underscoring not only the potential of coenzyme Q10 in mitigating liver steatosis but also its role in significantly boosting cardiovascular health.
Overall, by the end of our six-month research period, we observed a marked connection between improvements in liver function and cardiovascular markers, suggesting that coenzyme Q10 might be a beneficial treatment for those grappling with MASLD and associated cardiovascular risks.
Our findings revealed that those taking coenzyme Q10 experienced significant improvements in several cardiovascular and liver health markers. Specifically, we noted reduced liver fat and enhanced endothelial function, indicating healthier blood vessels. Measurements showed positive changes in their vascular and myocardial functions, which are critical indicators of heart health.
Conversely, patients in the placebo group did not show any improvement throughout the study period. The results were compelling, underscoring not only the potential of coenzyme Q10 in mitigating liver steatosis but also its role in significantly boosting cardiovascular health.
Overall, by the end of our six-month research period, we observed a marked connection between improvements in liver function and cardiovascular markers, suggesting that coenzyme Q10 might be a beneficial treatment for those grappling with MASLD and associated cardiovascular risks.
Read More
9
We aimed to understand how Coenzyme Q10 (CoQ10) might help counteract the damage caused by doxorubicin, a common chemotherapy drug known for its harmful side effects on the heart and lungs. To investigate this, we conducted a study involving 27 rats divided into three groups: one group received CoQ10, another received doxorubicin, and the last group received both.
At the end of the study, we examined the hearts and lungs of the rats. Our findings revealed that doxorubicin led to significant harm to the cellular structures in both organs, confirming the drug's cardiotoxic and pulmonary damaging effects. However, when CoQ10 was administered, it showed a promising ability to alleviate these adverse effects, almost restoring the normal appearance of the tissues.
In summary, our study suggests that CoQ10 could act as a protective agent, helping to maintain healthy lung and heart tissues in the context of doxorubicin treatment. This could potentially offer a valuable strategy for enhancing the safety and efficacy of chemotherapy regimens.
At the end of the study, we examined the hearts and lungs of the rats. Our findings revealed that doxorubicin led to significant harm to the cellular structures in both organs, confirming the drug's cardiotoxic and pulmonary damaging effects. However, when CoQ10 was administered, it showed a promising ability to alleviate these adverse effects, almost restoring the normal appearance of the tissues.
In summary, our study suggests that CoQ10 could act as a protective agent, helping to maintain healthy lung and heart tissues in the context of doxorubicin treatment. This could potentially offer a valuable strategy for enhancing the safety and efficacy of chemotherapy regimens.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Boosted immunity
1 people found this helpful
Since taking Coenzyme Q10, I have experienced improved immune system function and have aided my cardiovascular disease.
Read More
7.5
Good for wellness
It is a good form for digestibility. The small capsules are easy to drink and swallow. It greatly helps with wellness, cardiovascular health, and beauty. I take two capsules daily as advised by my endocrinologist.
Read More
7.5
Very helpful
A very good product that has truly assisted me with my cardiovascular health.
Read More
7.5
Prevents heart diseases
2 people found this helpful
Great tool! I take it for the prevention of cardiovascular diseases. Coenzyme Q10 is my number one remedy; I completely trust this manufacturer!
Read More
7.5
Proven benefits
1 people found this helpful
The Now brand was highly recommended by our integrative physician for quality. I chose CoQ10 to support cholesterol levels and cardiovascular health, and it has shown proven benefits.
Read More
Frequently Asked Questions
7.5
Boosted immunity
1 people found this helpful
Since taking Coenzyme Q10, I have experienced improved immune system function and have aided my cardiovascular disease.
7.5
Good for wellness
It is a good form for digestibility. The small capsules are easy to drink and swallow. It greatly helps with wellness, cardiovascular health, and beauty. I take two capsules daily as advised by my endocrinologist.
7.5
Proven benefits
1 people found this helpful
The Now brand was highly recommended by our integrative physician for quality. I chose CoQ10 to support cholesterol levels and cardiovascular health, and it has shown proven benefits.
7.5
Very helpful
A very good product that has truly assisted me with my cardiovascular health.
7.5
Boosts energy
It's a great product. It helps with cardiovascular health, energy levels, and mental clarity.
9
We explored the effects of coenzyme Q10 (CoQ-10) on heart failure (HF) patients by analyzing past literature. Our systematic review examined studies from MEDLINE and the Cochrane Library, focusing on how CoQ-10 influences outcomes like HF-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.
In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.
In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
We explored the effects of coenzyme Q10 (CoQ10) on heart health in a study involving male rats with diabetes-induced heart disease, known as diabetic cardiomyopathy. To investigate the potential benefits, researchers used a controlled experiment design, where rats were divided into groups receiving various treatments, including CoQ10 in a solution and a special formulation encapsulated in nanoliposomes, alongside a technique called ultrasound-targeted microbubble destruction (UTMD).
After 12 weeks, we observed that the group treated with CoQ10-PEG-lips combined with UTMD experienced improvements in heart function and reduced signs of heart damage compared to the diabetic group without treatment. The results indicated better myocardial integrity, antioxidant levels, and lower indicators of cell apoptosis—a process where cells self-destruct. However, when comparing the CoQ10-PEG-lips group and the CoQ10 with UTMD treatment group to the normal control group, the differences in heart measurements were not statistically significant.
Ultimately, the combination approach appears to effectively reduce heart cell damage in diabetic rats, but the data indicated that CoQ10 alone might not produce significant changes without the support of additional treatment forms. It's important to note the enhanced delivery method using UTMD seemed crucial for achieving these effects, suggesting that simply using CoQ10 in isolation might not yield the same positive outcomes.
After 12 weeks, we observed that the group treated with CoQ10-PEG-lips combined with UTMD experienced improvements in heart function and reduced signs of heart damage compared to the diabetic group without treatment. The results indicated better myocardial integrity, antioxidant levels, and lower indicators of cell apoptosis—a process where cells self-destruct. However, when comparing the CoQ10-PEG-lips group and the CoQ10 with UTMD treatment group to the normal control group, the differences in heart measurements were not statistically significant.
Ultimately, the combination approach appears to effectively reduce heart cell damage in diabetic rats, but the data indicated that CoQ10 alone might not produce significant changes without the support of additional treatment forms. It's important to note the enhanced delivery method using UTMD seemed crucial for achieving these effects, suggesting that simply using CoQ10 in isolation might not yield the same positive outcomes.
9
We explored the effectiveness of coenzyme Q10 in treating heart failure through a thorough analysis of various randomized controlled trials. Our investigation involved a comprehensive search across numerous databases, looking specifically for studies that focused on the impact of coenzyme Q10 on heart failure patients.
The findings were quite promising. We observed that coenzyme Q10 not only reduced the rate of all-cause mortality but also decreased hospitalizations due to heart failure. Improvements were noted in several key health metrics such as the New York Heart Association classification and brain natriuretic peptide levels. Furthermore, participants benefited from enhanced left ventricular ejection fraction and better performance on the six-minute walk test.
Importantly, these benefits were achieved without major adverse effects, suggesting that coenzyme Q10 could be a safe and effective option for those managing heart failure. Overall, our analysis indicates that coenzyme Q10 offers significant advantages for heart failure patients, enhancing their quality of life and potentially extending longevity.
The findings were quite promising. We observed that coenzyme Q10 not only reduced the rate of all-cause mortality but also decreased hospitalizations due to heart failure. Improvements were noted in several key health metrics such as the New York Heart Association classification and brain natriuretic peptide levels. Furthermore, participants benefited from enhanced left ventricular ejection fraction and better performance on the six-minute walk test.
Importantly, these benefits were achieved without major adverse effects, suggesting that coenzyme Q10 could be a safe and effective option for those managing heart failure. Overall, our analysis indicates that coenzyme Q10 offers significant advantages for heart failure patients, enhancing their quality of life and potentially extending longevity.
9
We aimed to understand how Coenzyme Q10 (CoQ10) might help counteract the damage caused by doxorubicin, a common chemotherapy drug known for its harmful side effects on the heart and lungs. To investigate this, we conducted a study involving 27 rats divided into three groups: one group received CoQ10, another received doxorubicin, and the last group received both.
At the end of the study, we examined the hearts and lungs of the rats. Our findings revealed that doxorubicin led to significant harm to the cellular structures in both organs, confirming the drug's cardiotoxic and pulmonary damaging effects. However, when CoQ10 was administered, it showed a promising ability to alleviate these adverse effects, almost restoring the normal appearance of the tissues.
In summary, our study suggests that CoQ10 could act as a protective agent, helping to maintain healthy lung and heart tissues in the context of doxorubicin treatment. This could potentially offer a valuable strategy for enhancing the safety and efficacy of chemotherapy regimens.
At the end of the study, we examined the hearts and lungs of the rats. Our findings revealed that doxorubicin led to significant harm to the cellular structures in both organs, confirming the drug's cardiotoxic and pulmonary damaging effects. However, when CoQ10 was administered, it showed a promising ability to alleviate these adverse effects, almost restoring the normal appearance of the tissues.
In summary, our study suggests that CoQ10 could act as a protective agent, helping to maintain healthy lung and heart tissues in the context of doxorubicin treatment. This could potentially offer a valuable strategy for enhancing the safety and efficacy of chemotherapy regimens.
References
- Alghibiwi HK, Alhusiani AM, Sarawi WS, Fadda L, Alomar HA, et al. Coenzyme Q10 and its liposomal form prevent copper cardiotoxicity by attenuating oxidative stress, TLR-4/NF-κB signaling and necroptosis in rats. Cell Mol Biol (Noisy-le-grand). 2025;71:118. doi:10.14715/cmb/2025.70.1.13
- Zhang M, Sun MY, He WY, Yu SF, Ma WC. [Experimental study on the treatment of diabetic cardiomyopathy in rats by using ultrasound-targeted microbubble destruction combined with coenzyme Q10 loaded long-circulating nanoliposomes]. Zhonghua Yi Xue Za Zhi. 2024;104:3765. doi:10.3760/cma.j.cn112137-20240605-01273
- Xu J, Xiang L, Yin X, Song H, Chen C, et al. Efficacy and safety of coenzyme Q10 in heart failure: a meta-analysis of randomized controlled trials. BMC Cardiovasc Disord. 2024;24:592. doi:10.1186/s12872-024-04232-z
- Qazi SU, Bin Naeem MA, Umar M, Zahid MJ, Kan Changez MI, et al. Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis. Future Cardiol. 2024;20:221. doi:10.1080/14796678.2024.2352308
- Intan RE, Balti DR, Nugraha RA, Alkaff FF, Salamah S, et al. Angiotensin converting enzyme inhibitor and coenzyme Q10 as adjunctive treatment for patients with ventricular septal rupture following late onset myocardial infarction: a case report. J Pak Med Assoc. 2024;74:S81. doi:10.47391/JPMA.S6-ACSA-16
- Vrentzos E, Ikonomidis I, Pavlidis G, Katogiannis K, Korakas E, et al. Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial. Cardiovasc Diabetol. 2024;23:245. doi:10.1186/s12933-024-02326-8
- Ali S, Sulaiman E, Dhiaa S. HISTOLOGICAL EFFECTS OF CO ENZYME Q10 ON DOXORUBICIN-INDUCED DEFICITS OF CARDIOPULMONARY AXIS IN WHITE ALBINO RATS. Georgian Med News. 2024.
- Alehagen U, Aaseth J, Schomburg L, Larsson A, Opstad T, et al. Selenoprotein P increases upon selenium and coenzyme Q supplementation and is associated with telomere length, quality of life and reduced inflammation and mortality. Free Radic Biol Med. 2024;222:403. doi:10.1016/j.freeradbiomed.2024.06.027
- Zeng M, Chen Z, Zhang Y, Pang Y. Combination of trimetazidine and coenzyme Q10 for the treatment of acute viral myocarditis: a systematic review and meta-analysis. J Infect Dev Ctries. 2024;18:658. doi:10.3855/jidc.18776
- Du H, Zhao Y, Wen J, Dai B, Hu G, et al. LncRNA DCRT Protects Against Dilated Cardiomyopathy by Preventing NDUFS2 Alternative Splicing by Binding to PTBP1. Circulation. 2024;150:1030. doi:10.1161/CIRCULATIONAHA.123.067861
